Poly-microbial Infections

Most of the infections occur due to multi-specie colonization by pathogens and within such multi-species infections, pathogens unveil distinctive communications that affect the severity of disease. A little is known about interspecies interactions in poly-microbial infections. Studying interactions among species of different niches and adaptive processes prompting co- or poly-microbial infections is now evidently important. Poly-microbial infection is associated with extensive need for antibiotics compared with patients with mono-infection suggesting that an interaction may happen between microbial species.

Antibacterial activity of P. aeruginosa 
was seen against S. aureus

It has been proposed that Staphylococcus aureus could set up the respiratory tract epithelia of cystic fibrosis patients to promote subsequent colonization of Pseudomonas aeruginosa. Antibacterial activity of P. aeruginosa was seen against S. aureus. P. aeruginosa not just repressed the growth of S. aureus on agar plate yet its cell free extract also has got anti- S. aureus metabolites as depicted in the Figure. This observation was further confirmed by co-culture study where we found that strain of P. aeruginosa outcompetes and arrests the growth of S. aureus. Taken together, these outcomes demonstrate that the strain of P. aeruginosa is capable of killing of planktonic growth of S. aureus, showing negative relationship between two life forms. Our study demonstrates that infection of S. aureus together with P. aeruginosa exacerbates the severity of host pathogenesis by elevating inflammatory cytokine immune responses of the host.